Pseudoephedrine is also used as a first-line prophylactic for recurrent priapism. Pseudoephedrine is also indicated for vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Pseudoephedrine is indicated for the treatment of nasal congestion, sinus congestion and Eustachian tube congestion. According to one study, pseudoephedrine may show effectiveness as an antitussive drug (suppression of cough). Due to its stimulating qualities, however, the oral preparation is more likely to cause adverse effects, including urinary retention. Pseudoephedrine can be used either as oral or as topical decongestant. The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Other beneficial effects may include increasing the drainage of sinus secretions, and opening of obstructed Eustachian tubes.

It reduces tissue hyperemia, edema, and nasal congestion commonly associated with colds or allergies. Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. A selection of over-counter medications, including Contac, which contains pseudoephedrine

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